2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl-
4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE
CAS: 39674-97-0
Molecular Formula: C14H11NO3
2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl- - Names and Identifiers
2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl- - Physico-chemical Properties
| Molecular Formula | C14H11NO3 |
| Molar Mass | 241.24 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Boling Point | 400.8±55.0 °C(Predicted) |
| Solubility | DMSO: 18mg/mL |
| Appearance | solid |
| Color | red |
| pKa | 5.78±0.40(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of the signal. BVT948 appears to be an effective inhibitor of both protein tyrosine phosphatases (PTP activity and P450 activity). BVT948 efficiently and selectively suppresses cellular H4 lysine 20 (H4K20me1) at doses lower than 5 μM within 24 h. The cells treated with BVT948 recapitulate cell-cycle-arrest phenotypes similar to what are reported for knocking down SETD8 by RNAi. Treatment of MCF-7 cells with 0.5, 1 or 5 μM of BVT948 for 24 h does not cause any significant changes in cell viability. BVT948 inhibits TPA-induced MMP-9 up-regulation in a dose-dependent manner. Treatment with BVT948 inhibits TPA-stimulated NF-κB binding activity, but not AP-1 binding activity. BVT948 does not affect the MAPK phosphorylation by TPA. Treatment with BVT948 diminishes the TPA-induced cell invasion by 50%. |
| In vivo study | Results show that 3 μmol/kg BVT948 (BVT.948) significantly enhances glucose clearance from the blood stream in response to insulin compare with vehicle-treated controls. |
2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.145 ml | 20.726 ml | 41.452 ml |
| 5 mM | 0.829 ml | 4.145 ml | 8.29 ml |
| 10 mM | 0.415 ml | 2.073 ml | 4.145 ml |
| 5 mM | 0.083 ml | 0.415 ml | 0.829 ml |
Last Update：2024-01-02 23:10:35
2H-Benz[g]indole-2,5(3H)-dione, 4-hydroxy-3,3-dimethyl- - Reference Information
| biological activity | BVT948 is an inhibitor of protein tyrosine phosphatase (PTP), several cytochrome P450 (P450) isomers and Lysine Methyltransferase SETD8 (KMT5A) can also be inhibited. |
| Target | PTP, P450, SETD8 |
Last Update：2024-04-09 19:05:16
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Product Name: 4-HYDROXY-3,3-DIMETHYL-2H-BENZO[G]INDOLE-2,5(3H)-DIONE Visit Supplier Webpage Request for quotation
CAS: 39674-97-0
Tel: 18301782025
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CAS: 39674-97-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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